Whole-exome sequencing identifies ADGB as a novel causative gene for male infertility in humans: from motility to fertilization.
Yang GaoLiting LiuShixiong TianChunyu LiuMingrong LvHuan WuDongdong TangBing SongQunshan ShenYuping XuPing ZhouZhaolian WeiFeng ZhangYunxia CaoXiao-Jin HePublished in: Andrology (2024)
Our findings provide new information for the molecular diagnosis of asthenoteratozoospermia and valuable reference for personalized genetic counselling and clinical treatment for these patients. The underlying risk of IVF failure behind sperm defects was highlighted.
Keyphrases
- genome wide
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- copy number
- prognostic factors
- peritoneal dialysis
- gene expression
- pregnant women
- smoking cessation
- escherichia coli
- health information
- type diabetes
- metabolic syndrome
- skeletal muscle
- staphylococcus aureus
- men who have sex with men
- transcription factor
- patient reported
- hepatitis c virus
- replacement therapy
- hiv testing
- genome wide identification
- candida albicans