Recellularized bovine pericardium with autologous mesenchymal stem cells reduces immune activation.

Sabin J BozsoJimmy J H KangRyaan El-AndariDana BoeHannah HedtkeMichael C MoonDarren H FreedJeevan NagendranJeevan Nagendran

Published in: Xenotransplantation (2022)

Our results suggest that preventing initial immune activation with autologous MSC recellularization may be an effective approach to decrease the recipient immune response, preventing recipient immune recognition of xenogeneic tissue engineered heart valves, and potentially leading to reduction in SVD incidence.

Keyphrases

mesenchymal stem cells
immune response
bone marrow
cell therapy
heart failure
risk factors
platelet rich plasma
stem cells
umbilical cord
aortic valve
dendritic cells
coronary artery disease
inflammatory response
aortic valve replacement
transcatheter aortic valve replacement