Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of high-density lipoproteins and low-density lipoproteins in opposite ways.
Srividya VelagapudiDongdong WangFrancesco PotìRenata FeuerbornJerome RobertEveline SchlumpfMustafa YalcinkayaGrigorios PanteloglouAnton PotapenkoManuela SimoniLucia RohrerJerzy-Roch NoferArnold Von EckardsteinPublished in: Cardiovascular research (2024)
S1P3 regulates the transendothelial transport of HDL and LDL oppositely by SR-BI-dependent and SR-BI-independent mechanisms, respectively. This divergence supports a contention that lipoproteins pass the endothelial barrier by specifically regulated mechanisms rather than passive filtration.