Mutations of the glycine cleavage system genes possibly affect the negative symptoms of schizophrenia through metabolomic profile changes.

Akane YoshikawaFumichika NishimuraAya InaiYosuke EriguchiMasaki NishiokaAtsuhiko TakayaMamoru TochigiYoshiya KawamuraTadashi UmekageKayoko KatoTsukasa SasakiYoshiaki OhashiKazuya Iwamoto Kiyoto KasaiChihiro Kakiuchi

Published in: Psychiatry and clinical neurosciences (2018)

These results suggest that GCS rare variants possibly contribute to the pathophysiology of SCZ by affecting the negative symptoms through elevation of aspartate.

Keyphrases

bipolar disorder
sleep quality
genome wide
copy number
gene expression
dna binding
genome wide identification
bioinformatics analysis