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Dietary Protein Restriction Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy.

Ashley OrillionNur P DamayantiLi ShenRemi Adelaiye-OgalaHayley C AffrontiMay ElbannaSreenivasulu ChintalaMichael CiesielskiLuigi FontanaChinghai KaoBennett D ElzeyTimothy L RatliffDavid E NelsonDominic J SmiragliaScott I AbramsRoberto Pili
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Dietary protein restriction alters TAM activity and enhances the tumoricidal capacity of this critical innate immune cell type, providing the rationale for clinical testing of this supportive tool in patients receiving cancer immunotherapies.
Keyphrases
  • innate immune
  • papillary thyroid
  • amino acid
  • binding protein
  • clinical trial
  • squamous cell carcinoma