Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.
Naoto SoyaHaijin XuAriel RoldanZhengrong YangHaoxin YeFan JiangAiswarya PremchandarGuido VeitSusan P C ColeJohn KappesTamas HegedusGergely L LukacsPublished in: bioRxiv : the preprint server for biology (2023)
Allosteric interdomain communication and its modulation are critical determinants of ABCC-transporters post-translational conformational biogenesis, misfolding, and pharmacological rescue.