Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.

Naoto SoyaHaijin XuAriel RoldanZhengrong YangHaoxin YeFan JiangAiswarya PremchandarGuido VeitSusan P C ColeJohn KappesTamas HegedusGergely L Lukacs

Published in: bioRxiv : the preprint server for biology (2023)

Allosteric interdomain communication and its modulation are critical determinants of ABCC-transporters post-translational conformational biogenesis, misfolding, and pharmacological rescue.

Keyphrases

single molecule
molecular dynamics simulations
small molecule
cystic fibrosis
single cell
room temperature