Login / Signup

Zinc-Catalyzed Alkyne-Carbonyl Metathesis of Ynamides with Isatins: Stereoselective Access to Fully Substituted Alkenes.

Chaoqun AoXiaohan YangShikun JiaXinfang XuYanqiu YuanWenhao HuWenhao Hu
Published in: The Journal of organic chemistry (2019)
A zinc-catalyzed intermolecular alkyne-carbonyl metathesis reaction of ynamides with isatins followed by an amide to ester conversion has been developed, which produces the indolone derivatives with a fully substituted alkene species in good to high yields. The salient features of this reaction include the following: mild reaction conditions, an inexpensive zinc catalyst, a broad substrate scope, the excellent regiocontrol and stereoselectivity, and amenable to the gram scale.
Keyphrases
  • room temperature
  • oxide nanoparticles
  • molecular docking
  • ionic liquid
  • electron transfer
  • gram negative
  • highly efficient
  • multidrug resistant
  • carbon dioxide
  • amino acid
  • structure activity relationship