In this work, iron oxide (Fe 3 O 4 ) magnetic nanoparticles (MNPs) and graphene oxide (GO) nanosheets were prepared via the co-precipitation technique and the Modified Hummer method. Fe 3 O 4 MNPs and GO nanosheets were combined to prepare Fe 3 O 4 /GO nanocomposite and subsequently conjugated with Digitonin (DIG) in order to obtain a dual-targeted delivery system based on DIG/Fe 3 O 4 /GO nanocomposite. SEM images reveal the presence of Fe 3 O 4 MNPs at a scale of 100 nm, exhibiting dispersion between the GO nanosheets. Aggregation of the DIG/Fe 3 O 4 /GO nanocomposite was observed at various size scales. The XRD structural analysis confirms the crystal structure of the prepared samples. The Fe 3 O 4 MNPs demonstrated the main XRD-diffracted peaks. Also, GO nanosheets exhibit crystalline characteristics on the (001) and (002) planes. The predominant peaks observed in the DIG/GO/Fe 3 O 4 nanocomposite are attributed to the crystal phases of Fe 3 O 4 MNPs. The FT-IR vibrational modes observed in the GO/DIG/Fe 3 O 4 nanocomposite indicate the presence of crosslinking between GO nanosheet layers and the Fe 3 O 4 MNPs. The antioxidant activity of the prepared samples was measured and the DIG/GO/Fe 3 O 4 nanocomposite demonstrated a significantly high antioxidant activity in both 2-diphenyl-1-picrylhydrazyl (DPPH · ) and 2,2-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS ·+ ) tests.
Keyphrases
- reduced graphene oxide
- quantum dots
- gold nanoparticles
- visible light
- highly efficient
- iron oxide
- magnetic nanoparticles
- carbon nanotubes
- photodynamic therapy
- solid phase extraction
- gene expression
- single cell
- drug delivery
- machine learning
- deep learning
- cancer therapy
- optical coherence tomography
- aqueous solution
- dna methylation
- molecular dynamics simulations
- simultaneous determination