Association between SNPs and Loss of Methylation Site on the CpG island of the Promoter Region of the Smoothened Gene, Potential Molecular Markers for Susceptibility to the Development of Basal Cell Carcinoma in the Brazilian Population.

Augusto Monteiro de SouzaOtávio Sérgio LopesAndressa de Lima LiberatoPaulo Junior Ribeiro de OliveiraSylvia Satomi Takeno HerreroAgnaldo Luiz do NascimentoCarlos Alberto LonguiIvan Rodrigues de Carvalho FilhoLeonardo Ferreira SoaresRenally Barbosa da SilvaRommel Rodriguez BurbanoPlínio DelatorreEleonidas Moura Lima

Published in: Asian Pacific journal of cancer prevention : APJCP (2020)

100 samples of paraffined tissue from patients with histopathological diagnosis of BCC and 100 control samples were analyzed for each polymorphism by a newly developed genotyping method, the Dideoxy Single Allele Specific - PCR. The software Bioestat - version 5.3 and Haploview 4.2 were used for the statistical analysis. For all tests a P-value.

Keyphrases

genome wide
dna methylation
basal cell carcinoma
copy number
gene expression
psychometric properties
high throughput
single molecule
human health
real time pcr