Rapid differentiation of xylazine metabolites using SLIM IM-MS.
Ralph AderorhoShadrack Wilson LucasChristopher D ChouinardPublished in: Analytical methods : advancing methods and applications (2024)
Xylazine represents an increased threat to the recreational drug market. In this study, we present a rapid strategy for identifying xylazine and differentiating its common isomeric metabolites using Structures for Lossless Ion Manipulations (SLIM) ion mobility coupled to high-resolution/tandem mass spectrometry (IM-HRMS/MS). Chemical derivatization using dansyl chloride also assisted with separations and led to identification of resolvable reaction product atropisomers.
Keyphrases
- tandem mass spectrometry
- ms ms
- high resolution
- mass spectrometry
- ultra high performance liquid chromatography
- liquid chromatography
- high performance liquid chromatography
- gas chromatography
- high resolution mass spectrometry
- simultaneous determination
- solid phase extraction
- liquid chromatography tandem mass spectrometry
- capillary electrophoresis
- multiple sclerosis
- loop mediated isothermal amplification
- health insurance
- contrast enhanced
- magnetic resonance
- gas chromatography mass spectrometry
- bioinformatics analysis
- emergency department