CSF NFL in a Longitudinally Assessed PD Cohort: Age Effects and Cognitive Trajectories.

Stefanie LercheIsabel WursterBenjamin RöbenMilan ZimmermannGerrit MachetanzSarah WiethoffMonique DehnertLea RietschelBenjamin RiebenbauerChristian DeuschleElke StranskyInga Lieplt-ScarfoneThomas GasserKathrin Brockmann

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

Increased CSF levels of neurofilament light protein are associated with cognitive decline and motor impairment in PD. However, this increase seems not a very early event and does not mark the conversion to cognitive impairment beforehand. Therefore, the predictive value needs to be discussed critically. © 2020 International Parkinson and Movement Disorder Society.

Keyphrases

cognitive decline
cognitive impairment
mild cognitive impairment
cerebrospinal fluid
depressive symptoms
protein protein
amino acid
small molecule