The highly expressed calcium-insensitive synaptotagmin-11 and synaptotagmin-13 modulate insulin secretion.
Jones K OforiAlexandros KaragiannopoulosMohammad BarghouthMototsugu NagaoMarkus E AnderssonVishal A SalunkheEnming ZhangAnna WendtLena EliassonPublished in: Acta physiologica (Oxford, England) (2022)
SYT11 and SYT13 have similar localization and transcriptional regulation, but they regulate insulin secretion differentially. While downregulation of SYT11 might be a compensatory mechanism in type-2 diabetes, downregulation of SYT13 reduces the insulin secretory response and overrules the compensatory regulation of SYT11 in a way that could aggravate the disease.