Login / Signup

Retinal neurodegeneration in age-related macular degeneration.

Costanza BarresiSumit Randhir SinghRosa Dolz-MarcoRobero Gallego-PinazoAlessandro BerniFrancesco Maria BandelloEnrico Borrelli
Published in: European journal of ophthalmology (2023)
Age-related macular degeneration (AMD) is a complex and multifactorial disease characterized by the damage of the unit comprised of the photoreceptors, retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris. Although the outer retina appears to be mainly affected in this disorder, several evidences exhibit that also the inner retina may be impaired. In this review we will provide a description of the prominent histologic and imaging findings suggesting an inner retinal loss in these eyes. In details, structural optical coherence tomography (OCT) technology proved either the inner and outer retina is impacted by AMD and that these two impairments are associated. Therefore, the purpose of this review is to provide a description of the role of neurodegeneration in AMD in order to better understand the relationship between neuronal loss and the outer retinal damage in this disease.
Keyphrases
  • age related macular degeneration
  • optical coherence tomography
  • diabetic retinopathy
  • optic nerve
  • oxidative stress
  • high resolution
  • photodynamic therapy