Dual roles of myeloid-derived suppressor cells in various diseases: a review.
Mahesh Raj NepalSajita ShahKyu-Tae KangPublished in: Archives of pharmacal research (2024)
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that originate from bone marrow stem cells. In pathological conditions, such as autoimmune disorders, allergies, infections, and cancer, normal myelopoiesis is altered to facilitate the formation of MDSCs. MDSCs were first shown to promote cancer initiation and progression by immunosuppression with the assistance of various chemokines and cytokines. Recently, various studies have demonstrated that MDSCs play two distinct roles depending on the physiological and pathological conditions. MDSCs have protective roles in autoimmune disorders (such as uveoretinitis, multiple sclerosis, rheumatoid arthritis, ankylosing spondylitis, type 1 diabetes, autoimmune hepatitis, inflammatory bowel disease, alopecia areata, and systemic lupus erythematosus), allergies, and organ transplantation. However, they play negative roles in infections and various cancers. Several immunosuppressive functions and mechanisms of MDSCs have been determined in different disease conditions. This review comprehensively discusses the associations between MDSCs and various pathological conditions and briefly describes therapeutic approaches.
Keyphrases
- multiple sclerosis
- induced apoptosis
- rheumatoid arthritis
- ankylosing spondylitis
- stem cells
- type diabetes
- systemic lupus erythematosus
- cell cycle arrest
- bone marrow
- disease activity
- papillary thyroid
- mesenchymal stem cells
- squamous cell carcinoma
- endoplasmic reticulum stress
- cardiovascular disease
- signaling pathway
- glycemic control
- white matter
- cell proliferation
- pi k akt
- childhood cancer