17β-Estradiol augments the neuroprotective effect of agomelatine in depressive- and anxiety-like behaviors in ovariectomized rats.

Yasmine A El-KhatibRabab Hamed SayedNada A SallamHala F ZakiMahmoud M Khattab

Published in: Psychopharmacology (2020)

E2 augmented the neuroprotective effect of Ago in OVX rats via its anti-inflammatory and neurotrophic effects. The combined treatment of E2 and Ago should be further investigated as a treatment of choice for depression, anxiety, and sleep disturbances associated with menopause.

Keyphrases

sleep quality
anti inflammatory
physical activity
postmenopausal women
combination therapy
brain injury
mass spectrometry
high resolution
blood brain barrier
stress induced
subarachnoid hemorrhage