Attenuating the Epidermal Growth Factor Receptor-Extracellular Signal-Regulated Kinase-Sex-Determining Region Y-Box 9 Axis Promotes Liver Progenitor Cell-Mediated Liver Regeneration in Zebrafish.

Juhoon SoMinwook KimSeung-Hoon LeeSungjin KoDaniel A LeeHyewon ParkMizuki AzumaMichael J ParsonsDavid ProberDonghun Shin

Published in: Hepatology (Baltimore, Md.) (2021)

The EGFR-ERK-SOX9 axis suppresses LPC-to-hepatocyte differentiation during LPC-mediated liver regeneration. We suggest EGFR inhibitors as a proregenerative therapeutic drug for patients with advanced liver disease.

Keyphrases

epidermal growth factor receptor
tyrosine kinase
stem cells
advanced non small cell lung cancer
transcription factor
small cell lung cancer
signaling pathway
cell proliferation
emergency department
binding protein
liver injury