Advances in the Therapeutic Effects of Apoptotic Bodies on Systemic Diseases.
Xiaoyan LiYitong LiuXu LiuJuan DuUjjal Kumar BhawalJunji XuLijia GuoYi LiuPublished in: International journal of molecular sciences (2022)
Apoptosis plays an important role in development and in the maintenance of homeostasis. Apoptotic bodies (ApoBDs) are specifically generated from apoptotic cells and can contain a large variety of biological molecules, which are of great significance in intercellular communications and the regulation of phagocytes. Emerging evidence in recent years has shown that ApoBDs are essential for maintaining homeostasis, including systemic bone density and immune regulation as well as tissue regeneration. Moreover, studies have revealed the therapeutic effects of ApoBDs on systemic diseases, including cancer, atherosclerosis, diabetes, hepatic fibrosis, and wound healing, which can be used to treat potential targets. This review summarizes current research on the generation, application, and reconstruction of ApoBDs regarding their functions in cellular regulation and on systemic diseases, providing strong evidence and therapeutic strategies for further insights into related diseases.
Keyphrases
- cell death
- cell cycle arrest
- wound healing
- cardiovascular disease
- type diabetes
- stem cells
- oxidative stress
- induced apoptosis
- anti inflammatory
- drug induced
- papillary thyroid
- glycemic control
- squamous cell carcinoma
- single cell
- bone mineral density
- young adults
- cell proliferation
- adipose tissue
- postmenopausal women
- bone loss
- soft tissue
- insulin resistance