Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct.

Grace O Adeniyi-Ipadeola Julia D HankinsAmal KambalXi-Lei ZengKetki Patil Victoria PoplaskiCarolyn BomidiHoa Nguyen-PhucSandra L GrimmCristian CoarfaSue E CrawfordSarah E BluttAllison L SpeerMary K EstesSasirekha Ramani

Published in: bioRxiv : the preprint server for biology (2023)

HIEs established from infant intestinal tissues reflect characteristics of the infant gut and are distinct from adult cultures. Our data support the use of infant HIEs as an ex-vivo model to advance studies of infant-specific diseases and drug discovery for this population.

Keyphrases

drug discovery
endothelial cells
induced pluripotent stem cells
young adults
machine learning
big data
childhood cancer