Proliferative mechanism of benign prostatic hyperplasia by NLRP3 inflammasome through the complement pathway.

Junya Hata Kanako MatsuokaYuki HariganeKei YaginumaHidenori AkaihataSatoru MeguroRuriko Honda-TakinamiAkifumi OnagiYuichi SatoSoichiro OgawaMotohide UemuraYoshiyuki Kojima

Published in: International journal of urology : official journal of the Japanese Urological Association (2024)

NLRP3 inflammasome activation by complement C5a produces IL-1β and IL-18 through Caspase-1 during the BPH proliferative process. NLRP3 inflammasome have the possibilities to be a therapeutic target for BPH proliferation by inhibiting the NLRP3 inflammasome pathway.

Keyphrases

nlrp inflammasome
benign prostatic hyperplasia
lower urinary tract symptoms
signaling pathway
cell death
oxidative stress