Login / Signup

A multimodal marker for cognitive functioning in multiple sclerosis: the role of NfL, GFAP and conventional MRI in predicting cognitive functioning in a prospective clinical cohort.

Maureen van DamBrigit A de JongEline A J WillemseIlse M NautaMarijn HuiskampMartin KleinBastiaan MoraalSanne de Geus-DriessenJeroen J G GeurtsBernard M J UitdehaagCharlotte E TeunissenHanneke E Hulst
Published in: Journal of neurology (2023)
Fluid and imaging (bio)markers reflect different aspects of neurodegeneration and cannot be used interchangeably as markers for cognitive functioning in PwMS. The use of a multimodal marker, i.e., the combination of grey matter volume and sNfL, seems most promising for detecting cognitive deficits in MS.
Keyphrases
  • multiple sclerosis
  • high resolution
  • white matter
  • pain management
  • mass spectrometry
  • magnetic resonance imaging
  • ms ms
  • magnetic resonance
  • computed tomography
  • contrast enhanced