A multimodal marker for cognitive functioning in multiple sclerosis: the role of NfL, GFAP and conventional MRI in predicting cognitive functioning in a prospective clinical cohort.

Maureen van DamBrigit A de JongEline A J WillemseIlse M NautaMarijn HuiskampMartin KleinBastiaan MoraalSanne de Geus-DriessenJeroen J G GeurtsBernard M J UitdehaagCharlotte E TeunissenHanneke E Hulst

Published in: Journal of neurology (2023)

Fluid and imaging (bio)markers reflect different aspects of neurodegeneration and cannot be used interchangeably as markers for cognitive functioning in PwMS. The use of a multimodal marker, i.e., the combination of grey matter volume and sNfL, seems most promising for detecting cognitive deficits in MS.

Keyphrases

multiple sclerosis
high resolution
white matter
pain management
mass spectrometry
magnetic resonance imaging
ms ms
magnetic resonance
computed tomography
contrast enhanced