A multimodal marker for cognitive functioning in multiple sclerosis: the role of NfL, GFAP and conventional MRI in predicting cognitive functioning in a prospective clinical cohort.
Maureen van DamBrigit A de JongEline A J WillemseIlse M NautaMarijn HuiskampMartin KleinBastiaan MoraalSanne de Geus-DriessenJeroen J G GeurtsBernard M J UitdehaagCharlotte E TeunissenHanneke E HulstPublished in: Journal of neurology (2023)
Fluid and imaging (bio)markers reflect different aspects of neurodegeneration and cannot be used interchangeably as markers for cognitive functioning in PwMS. The use of a multimodal marker, i.e., the combination of grey matter volume and sNfL, seems most promising for detecting cognitive deficits in MS.