Inclusion of dosimetric data as covariates in toxicity-related radiogenomic studies : A systematic review.

Noorazrul Azmie YahyaXin-Jane ChuaHanani A MananFuad Ismail

Published in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2018)

A large proportion of studies on the correlation of genetic markers with radiotherapy-related side effects considered no dosimetric parameters. Significance of dose distribution features was found in more than half of the studies including these features, emphasizing their importance. Completeness of radiation-specific clinical data may have increased in recent years which may improve gene-toxicity association studies.

Keyphrases

radiation therapy
case control
oxidative stress
early stage
electronic health record
copy number
gene expression
machine learning
dna methylation
transcription factor
data analysis
deep learning
drug induced