Login / Signup

The PI3K/Akt/mTOR pathway as a preventive target in melanoma brain metastasis.

Cedric TehranianLaura FankhauserPatrick N HarterColin D H RatcliffePia S ZeinerJulia M MessmerDirk C HoffmannKatharina FreyDana WestphalMichael W RonellenfitschErik SahaiWolfgang WickMatthia A KarremanFrank Winkler
Published in: Neuro-oncology (2021)
These findings establish a key role of PAM pathway activation for critical steps of early metastatic brain colonization and reveal its pharmacological inhibition as a potent avenue to prevent the formation of clinically relevant BM.
Keyphrases
  • resting state
  • white matter
  • squamous cell carcinoma
  • small cell lung cancer
  • functional connectivity
  • cerebral ischemia
  • genome wide
  • single cell
  • gene expression
  • dna methylation
  • subarachnoid hemorrhage