The PI3K/Akt/mTOR pathway as a preventive target in melanoma brain metastasis.
Cedric TehranianLaura FankhauserPatrick N HarterColin D H RatcliffePia S ZeinerJulia M MessmerDirk C HoffmannKatharina FreyDana WestphalMichael W RonellenfitschErik SahaiWolfgang WickMatthia A KarremanFrank WinklerPublished in: Neuro-oncology (2021)
These findings establish a key role of PAM pathway activation for critical steps of early metastatic brain colonization and reveal its pharmacological inhibition as a potent avenue to prevent the formation of clinically relevant BM.