Safety and Efficacy of Neoadjuvant Chemoimmunotherapy in Gastric Cancer Patients with a PD-L1 Positive Status: A Case Report.

Alexandra V AvgustinovichOlga V BakinaSergey G Afanas'evLiudmila V SpirinaAlexander M Volkov

Published in: Current issues in molecular biology (2023)

FLOT chemotherapy combined with immune checkpoint inhibitors showed high efficacy in gastric cancer patients with a positive PD-L1 status. Autophagy was involved in activating the tumor immunity. Further research is needed to clarify the mechanism of effective anticancer treatment.

Keyphrases

locally advanced
signaling pathway
rectal cancer
cell death
lymph node
oxidative stress
endoplasmic reticulum stress
squamous cell carcinoma
radiation therapy
chemotherapy induced