Identifying Good Candidates for Active Surveillance of Ductal Carcinoma In Situ : Insights from a Large Neoadjuvant Endocrine Therapy Cohort.
Alexa C GlencerPhoebe N MillerHeather I GreenwoodCristian K Maldonado RodasRita I FreimanisAmrita BasuRita A MukhtarCase BrabhamPaul KimE Shelley HwangJennifer M RosenbluthGillian L HirstMichael J CampbellAlexander D BorowskyLaura J EssermanPublished in: Cancer research communications (2022)
A retrospective analysis of 71 patients with DCIS who did not undergo upfront surgery demonstrated that breast MRI features after short-term exposure to endocrine therapy identify those at high (68.2%), intermediate (20.0%), and low risk (8.7%) of IDC. With 7.4 years mean follow-up, 52.1% of patients remain on active surveillance. A period of active surveillance offers the opportunity to risk-stratify DCIS lesions and guide decisions for operative management.
Keyphrases
- end stage renal disease
- ejection fraction
- magnetic resonance imaging
- newly diagnosed
- chronic kidney disease
- minimally invasive
- rectal cancer
- lymph node
- stem cells
- coronary artery disease
- coronary artery bypass
- mesenchymal stem cells
- computed tomography
- acute coronary syndrome
- locally advanced
- cell therapy
- radiation therapy
- bone marrow
- atrial fibrillation