Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging.

Sunao ShimizuJunsei MimuraTakanori HasegawaEigo ShimizuSeiya ImotoMichiko TsushimaShuya KasaiHiromi YamazakiYusuke UshidaHiroyuki SuganumaHirofumi TomitaMasayuki YamamotoShigeyuki NakajiKen Itoh

Published in: PloS one (2020)

This study is the first to show that SNP-617 affects the age-dependent increase in vascular stiffness. Our results indicate that low NRF2 activity induces premature vascular aging and could be targeted for the prevention of cardiovascular diseases associated with aging.

Keyphrases

oxidative stress
cardiovascular disease
gene expression
transcription factor
cancer therapy
metabolic syndrome
coronary artery disease