Time to onset in statistical signal detection revisited: A follow-up study in long-term onset adverse drug reactions.
Joep H G SchollFlorence P A M van HunselEelko HakEugene P van PuijenbroekPublished in: Pharmacoepidemiology and drug safety (2019)
Because of its low sensitivity, the developed TTO method cannot replace disproportionality analysis as a signal detection tool. It may be useful in combination with other methods.