In vitro gentamicin exposure alters caveolae protein profile in cochlear spiral ligament pericytes.

Elisa GhelfiYohann GrondinEmil J MilletAdam BartosMagda BortoniClara Oliveira Gomes Dos SantosHumberto J Trevino-VillarrealRosalinda SepulvedaRick Rogers

Published in: Proteome science (2018)

We report that gentamicin exposure modifies protein profile of caveolae from SL pericytes. We identified a pool of proteins which are uniquely segregating with caveolae during the treatment, mainly participating in metabolic and biosynthetic pathways, in transport pathways and in genetic information processing. Finally, we show for the first time proteins associated with caveolae SL pericytes linked to nonsyndromic hearing loss.

Keyphrases

hearing loss
protein protein
amino acid
binding protein
genome wide
gene expression
small molecule
copy number
combination therapy