High spatial endothelial shear stress gradient independently predicts site of acute coronary plaque rupture and erosion.
Vikas ThondapuChris MamonEric K W PoonOsamu KuriharaHyung Oh KimMichele RussoMakoto ArakiHiroki ShinoharaErika YamamotoJouke DijkstraMark TaceyHang LeeAndrew OoiPeter BarlisIk-Kyung JangPublished in: Cardiovascular research (2022)
High ESSG is independently associated with plaque rupture while high ESSG, ESS, and OSI associate with plaque erosion. While ESSG is higher at rupture sites than erosion sites, OSI is higher at erosion sites and ESS was similar. These results suggest that ESSG and OSI may play critical roles in acute plaque rupture and erosion, respectively.