A role for the cortex in sleep-wake regulation.
Lukas B KroneTomoko YamagataCristina Blanco-DuqueMathilde C C GuillauminMartin C KahnVincent van der VinneLaura E McKillopShu K E TamStuart N PeirsonColin J AkermanAnna Hoerder-SuabedissenZoltán MolnárVladyslav V VyazovskiyPublished in: Nature neuroscience (2021)
Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis.