Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution.
Kristine LangthalerChristopher R JonesLasse SaabyChristoffer BundgaardBirger BrodinPublished in: Fluids and barriers of the CNS (2024)
values, underscores that the model may have potential for early-stage screening. With minor refinements, this in vitro approach could reduce the reliance on in vivo experiments, accelerating the pace of CNS drug discovery and promoting a more ethical research approach.
Keyphrases
- drug discovery
- early stage
- single cell
- multidrug resistant
- cell therapy
- blood brain barrier
- molecular dynamics
- resting state
- emergency department
- stem cells
- squamous cell carcinoma
- adverse drug
- multiple sclerosis
- molecular dynamics simulations
- drug induced
- radiation therapy
- functional connectivity
- subarachnoid hemorrhage
- electronic health record