ACSL4 inhibition prevents macrophage ferroptosis and alleviates fibrosis in bleomycin-induced systemic sclerosis model.

Dianyu CaoJina ZhengZheng LiYong YuZengrui ChenQiang Wang

Published in: Arthritis research & therapy (2023)

ACSL4 induces inflammatory macrophage ferroptosis to aggravate fibrosis progressing. ACSL4 and its upregulators of calpains may be potential therapeutic targets for BLM model of SSc.

Keyphrases

systemic sclerosis
interstitial lung disease
cell death
adipose tissue
mouse model
high glucose
diabetic rats
rheumatoid arthritis
drug induced
pulmonary fibrosis
endothelial cells