Stable high-oxidation-state complex in situ Mn(V)-Mn(III) transition to achieve highly efficient cervical cancer therapy.
Hanjie ZhangYuequn ZhangJianrong CaoLi MaTianfeng ChenPublished in: Chemical communications (Cambridge, England) (2022)
Designing metal complexes to target the vulnerable redox balance in cancer cells is a promising strategy to realize successful cancer therapy. The synthesized stable nitridomanganese(V) complex Mn V (N) (salen) not only reacts with GSH to achieve in situ Mn(V)-Mn(III) transformation to down-regulate the antioxidant system, but also catalyzes H 2 O 2 to higher oxidation capacity ROS to up-regulate the intracellular oxidative level, finally resulting in cancer cell death.
Keyphrases
- cell death
- highly efficient
- room temperature
- transition metal
- cancer therapy
- metal organic framework
- hydrogen peroxide
- oxidative stress
- drug delivery
- papillary thyroid
- reactive oxygen species
- stem cells
- squamous cell carcinoma
- dna damage
- mesenchymal stem cells
- cell cycle arrest
- squamous cell
- young adults
- fluorescent probe
- signaling pathway
- cell therapy