The role of DNA methylation in ovarian cancer chemoresistance: A narrative review.

Published in: Health science reports (2023)

Establishing a panel of aberrantly methylated chemoresistance-related genes to predict chemoresponsiveness and patients' suitability to DNMTi could significantly reduce OC recurrence, while improving DNMTi therapy viability. To achieve this, a large-scale prospective genome-wide DNA methylation profile study that spans different histotypes, includes paired samples (before and after chemotherapy), and integrates transcriptomic and methylomic analysis, is warranted.

Keyphrases

dna methylation
genome wide
end stage renal disease
gene expression
chronic kidney disease
copy number
prognostic factors
squamous cell carcinoma
bone marrow
stem cells
rna seq
locally advanced