Pre- and post-junctional bradykinin B2 receptors regulate smooth muscle tension to the pig intravesical ureter.
Ana S F RibeiroVítor S FernandesMaría Pilar MartínezMaría Elvira López-OlivaMaría Victoria BarahonaPaz RecioAna Cristina MartínezIgor BlahaLuis M OrensanzSalvador BustamanteAlbino García-SacristánDolores PrietoChristopher R ChapplePublished in: Neurourology and urodynamics (2014)
The present results suggest that BK produces contraction of pig intravesical ureter via smooth muscle B2 receptors coupled to extracellular Ca(2+) entry mainly via VOC (L-type) channels. Facilitatory neuronal B2 receptors modulating NO-dependent or independent NANC inhibitory neurotransmission are also demonstrated.