Screening of lysyl oxidase (LOX) and lysyl oxidase like (LOXL) enzyme expression and activity in preterm prelabor rupture of fetal membranes.

Jossimara PolettiniMarcia G SilvaMarian KacerovskyTariq A SyedGeorge R SaadeJossimara Polettini

Published in: Journal of perinatal medicine (2016)

Increase of LOX expression in pPROM, an OS-related disease, and the apparent inhibition of LOX activity by CSE restored by antioxidant treatment suggest that reactive oxygen species might influence LOX-mediated tissue remodeling in fetal membranes. Balanced antioxidant supplementation during pregnancy may reduce the risk of pPROM by increasing LOX activity.

Keyphrases

poor prognosis
low density lipoprotein
reactive oxygen species
oxidative stress
anti inflammatory
computed tomography
preterm birth
low birth weight
smoking cessation
replacement therapy