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In vitro cytotoxicity of human urine and its potential toxic parameters towards bladder cancer cells.

Hongda ZhaoRyan Tsz-Hei TseCarol Ka-Lo ChengChristine Yim-Ping WongAngel Wing-Yan KongRonald Cheong-Kin ChanPeter Ka-Fung ChiuChi-Fai NgJeremy Yuen-Chun Teoh
Published in: PloS one (2022)
Our study confirmed that there was not statistically significant difference in cytotoxicity between CaB and non-CaB urines. However, we identified some parameters that could have an impact on cytotoxicity towards CaB cells. Modifying certain urine characteristics peri-operatively may induce cytotoxicity, avoid tumour re-implantation, and reduce the chance of cancer recurrence.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • endothelial cells
  • endoplasmic reticulum stress
  • papillary thyroid
  • signaling pathway
  • oxidative stress
  • young adults
  • lymph node metastasis
  • childhood cancer