Maternal immune activation in neurodevelopmental disorders.

Cynthia M SolekNasr FarooqiMyriam VerlyTony K LimEdward S Ruthazer

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2017)

Converging lines of evidence from basic science and clinical studies suggest a relationship between maternal immune activation (MIA) and neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. The mechanisms through which MIA increases the risk of neurodevelopmental disorders have become a subject of intensive research. This review aims to describe how dysregulation of microglial function and immune mechanisms may link MIA and neurodevelopmental pathologies. We also summarize the current evidence in animal models of MIA. Developmental Dynamics 247:588-619, 2018. © 2017 Wiley Periodicals, Inc.

Keyphrases

autism spectrum disorder
attention deficit hyperactivity disorder
intellectual disability
bipolar disorder
birth weight
congenital heart disease
pregnancy outcomes
inflammatory response
lipopolysaccharide induced
pregnant women
spinal cord injury
body mass index
weight loss