Astrocytic outer retinal layer thinning is not a feature in AQP4-IgG seropositive neuromyelitis optica spectrum disorders.
Angelo LuHanna G ZimmermannSvenja SpecoviusSeyedamirhosein MotamediClaudia ChienCharlotte BereuterMarco A Lana-PeixotoMariana Andrade FontenelleFereshteh AshtariRahele KafiehAlireza DehghaniMohsen PouraziziLekha PanditAnitha D'CunhaHo Jin KimJae-Won HyunSu-Kyung JungLetizia LeocaniMarco PisaMarta RadaelliSasitorn SirithoEugene F MayCaryl TongcoJérôme De SèzeThomas SengerJacqueline PalaceAdriana Roca-FernándezMaria Isabel LeiteSrilakshmi M SharmaHadas Stiebel-KalishNasrin AsgariKerstin Kathrine SoelbergElena Hernandez Martinez-LapiscinaJoachim HavlaYang Mao-DraayerZoe RimlerAllyson ReidRomain MarignierAlvaro Cobo-CalvoAyse AltintasUygur TanriverdiRengin YildirimOrhan AktasMarius RingelsteinPhilipp AlbrechtIvan Maynart TavaresCarolina Martines EstruttiAnu JacobSaif HudaIbis Soto de CastilloAxel PetzoldAri J GreenMichael R YeamanTerry J SmithLawrence CookFriedemann PaulAlexander U BrandtFrederike Cosima Oertelnull nullPublished in: Journal of neurology, neurosurgery, and psychiatry (2021)
The results suggest that outer retinal layer loss is not a consistent component of retinal astrocytic damage in AQP4-IgG+ NMOSD. Longitudinal studies are necessary to determine if OPL and ONL are damaged in late disease due to retrograde trans-synaptic axonal degeneration and whether outer retinal dysfunction occurs despite any measurable structural correlates.