Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications.
John SidneyJose Luis VelaDave FriedrichRavi KollaMatthias von HerrathJohnna D WesleyAlessandro SettePublished in: BMC immunology (2018)
These results demonstrate that insulin-derived epitopes, commonly associated with T1D, generally bind HLA class I poorly, but can be subject to PTM that improve their binding capacity and may, in part, be responsible for T-cell activation in T1D and subsequent beta cell death.