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Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications.

John SidneyJose Luis VelaDave FriedrichRavi KollaMatthias von HerrathJohnna D WesleyAlessandro Sette
Published in: BMC immunology (2018)
These results demonstrate that insulin-derived epitopes, commonly associated with T1D, generally bind HLA class I poorly, but can be subject to PTM that improve their binding capacity and may, in part, be responsible for T-cell activation in T1D and subsequent beta cell death.
Keyphrases
  • cell death
  • type diabetes
  • glycemic control
  • cardiovascular disease
  • dna binding
  • binding protein
  • signaling pathway
  • skeletal muscle
  • adipose tissue
  • finite element