Studies on N-Acetyltransferase (NAT2) Genotype Relationships in Emiratis: Confirmation of the Existence of Phenotype Variation among Slow Acetylators.

Mohammad M Al-AhmadNaheed AmirSubramanian DhanasekaranAnne JohnYousef M AbdulrazzaqBassam R AliSalim M A Bastaki

Published in: Annals of human genetics (2017)

There is a high percentage of slow acetylators among Emiratis, which correlates with the presence of nonreference alleles for the NAT2 gene. Individuals who carried NAT2*6A/*6A, NAT2*6A/*7B, NAT2*7B/*7B, or NAT2*5A/*5B genotypes might be at higher risk of toxicity with some drugs and some diseases compared to others, as these genotypes are associated with the slowest acetylation status.

Keyphrases

oxidative stress
genome wide
copy number
dna methylation
drug induced
case control