Identification of the shared genes and immune signatures between systemic lupus erythematosus and idiopathic pulmonary fibrosis.
Sheng LiaoYouzhou TangYing ZhangQingtai CaoLinyong XuQuan ZhuangPublished in: Hereditas (2023)
This study originally uncovered the MAPK pathway, and the infiltration of some immune-cell subsets might be pivotal factors for pulmonary fibrosis complication in SLE, which could be used as potentially therapeutic targets. The cyclophosphamide may treat SLE-derived pulmonary fibrosis through interaction with PTGS2, which could be activated by p38MAPK.
Keyphrases
- pulmonary fibrosis
- systemic lupus erythematosus
- idiopathic pulmonary fibrosis
- disease activity
- genome wide
- bioinformatics analysis
- interstitial lung disease
- signaling pathway
- rheumatoid arthritis
- high dose
- oxidative stress
- pi k akt
- peripheral blood
- gene expression
- systemic sclerosis
- dna methylation
- transcription factor
- genome wide analysis