Epigenome-wide association study of adiposity and future risk of obesity-related diseases.

Gianluca CampanellaMarc J GunterSilvia PolidoroVittorio KroghDomenico PalliSalvatore PanicoCarlotta SacerdoteRosario TuminoGiovanni FioritoSimonetta GuarreraLicia IacovielloIngvar A BergdahlBeatrice MelinPer LennerTheo M C M de KokPanagiotis GeorgiadisJos C S KleinjansSoterios A KyrtopoulosH Bas Bueno-de-MesquitaKaren A LillycropAnne M MayN Charlotte Onland-MoretRobert MurrayElio RiboliMonique VerschurenEiliv LundNicolle ModeTorkjel M SandangerValentina FianoMorena TrevisanGiuseppe MatulloPhillippe Froguel Paul ElliottPaolo VineisMarc Chadeau-Hyam

Published in: International journal of obesity (2005) (2018)

Our results suggest that epigenetic changes, in particular altered DNA methylation patterns, may be an intermediate biomarker at the intersection of obesity and obesity-related diseases, and could offer clues as to underlying biological mechanisms.

Keyphrases

dna methylation
insulin resistance
metabolic syndrome
weight gain
weight loss
high fat diet induced
type diabetes
gene expression
genome wide
adipose tissue
skeletal muscle
body mass index
current status
physical activity
copy number