Integrating TSPO PET imaging and transcriptomics to unveil the role of neuroinflammation and amyloid-β deposition in Alzheimer's disease.

Miao ZhangXiao-Hang QianJialin HuYaoyu ZhangXiaozhu LinWangxi HaiKuangyu ShiXufeng JiangYao LiHui-Dong TangBiao Li

Published in: European journal of nuclear medicine and molecular imaging (2023)

By integrating transcriptomics and TSPO PET imaging in the same clinical AD cohort, this study revealed CD200 played an important role in regulating neuroinflammation, Aβ deposition and cognitive dysfunction.

Keyphrases

pet imaging
single cell
positron emission tomography
lipopolysaccharide induced
traumatic brain injury
lps induced
cognitive impairment
cerebral ischemia
cognitive decline
computed tomography
inflammatory response
blood brain barrier
nk cells
pet ct