Granulomatous meningoencephalitis and blindness associated with Mycobacterium tuberculosis complex infection in a senile female chimpanzee (Pan troglodytes).
Daniel Oliveira Dos SantosNayara Ferreira de PaulaThaynara Parente de CarvalhoLucas Dos Reis de SouzaHerlandes Penha TinocoCarlyle Mendes CoelhoAna Augusta SousaPaulo Martins Soares FilhoLuciana Rabello FerreiraTatiane Alves da PaixãoAyisa Rodrigues de OliveiraRenato de Lima SantosPublished in: Journal of medical primatology (2024)
A 40-year old female chimpanzee (Pan troglodytes) developed hyporexia, weight loss, followed by progressive and complete blindness. Tomography demonstrated an intracranial mass in the rostroventral brain involving the optic chiasm, with a presumptive diagnosis of neoplasm. However, histopathology revealed a granulomatous meningoencephalitis, and tissue samples tested positive for Mycobacterium tuberculosis.
Keyphrases
- mycobacterium tuberculosis
- weight loss
- interstitial lung disease
- pulmonary tuberculosis
- optic nerve
- multiple sclerosis
- bariatric surgery
- white matter
- optical coherence tomography
- systemic sclerosis
- resting state
- low grade
- gastric bypass
- type diabetes
- body mass index
- adipose tissue
- idiopathic pulmonary fibrosis
- weight gain
- high grade