Biology, vulnerabilities and clinical applications of circulating tumour cells.
Alexander RingBich Doan Nguyen-SträuliAndreas WickiNicola AcetoPublished in: Nature reviews. Cancer (2022)
In recent years, exceptional technological advances have enabled the identification and interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading to new fields of research and fostering the promise for paradigm-changing, liquid biopsy-based clinical applications. Analysis of CTCs has revealed distinct biological phenotypes, including the presence of CTC clusters and the interaction between CTCs and immune or stromal cells, impacting metastasis formation and providing new insights into cancer vulnerabilities. Here we review the progress made in understanding biological features of CTCs and provide insight into exploiting these developments to design future clinical tools for improving the diagnosis and treatment of cancer.
Keyphrases
- circulating tumor cells
- induced apoptosis
- papillary thyroid
- cell cycle arrest
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- endoplasmic reticulum stress
- prognostic factors
- oxidative stress
- lymph node metastasis
- squamous cell carcinoma
- signaling pathway
- cell death
- machine learning
- ultrasound guided
- single cell
- childhood cancer
- cell proliferation
- artificial intelligence
- current status
- deep learning