Localized alopecia and suppression of hypothalamic-pituitary-adrenal (HPA) axis in dogs following treatment with difluprednate 0.05% ophthalmic emulsion (Durezol®).
Katelin QuantzAmanda L AndersonChristine D HarmanErica L NolandJacquelyn M Del ValleLaurence M OccelliJessica B BurnSimon M Petersen-JonesDaniel K LangloisChris G PirieAnnette D PetersenAndrás M KomáromyPublished in: BMC veterinary research (2021)
In dogs long-term use of difluprednate ophthalmic emulsion results in HPA axis suppression and in some cases iatrogenic hyperadrenocorticism. A novel pattern of localized alopecia is suspected to be related to dermal absorption and local action due to superior potency and penetration compared to other commonly utilized ophthalmic corticosteroids.