Neocortical Slow Oscillations Implicated in the Generation of Epileptic Spasms.
Chih-Hong LeeJohn T LeCarlos J Ballester-RosadoAnne E AndersonJohn W SwannPublished in: Annals of neurology (2020)
Our findings provide evidence that epileptic spasms can arise from the neocortex and reveal a previously unappreciated interplay between brain state physiology and spasm generation. The identification of neocortical up states as a mechanism capable of initiating epileptic spasms will likely provide new targets for interventional therapies. ANN NEUROL 2021;89:226-241.