Severe cisplatin-induced renal toxicity in a patient with xeroderma pigmentosum.
Peter Jeffrey GilbarKhageshwor PokharelPublished in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2021)
Three cases of severe adverse effects from cisplatin administration in patients with Xeroderma pigmentosum have been reported, with all fatal. Xeroderma pigmentosum complementation group C plays an important role in the DNA repair process with the recognition and repair of damage to normal cells following cisplatin. Patients with Xeroderma pigmentosum can be carriers of defective Xeroderma pigmentosum complementation group C and if the degree of Xeroderma pigmentosum complementation group C inactivity is significant, fatalities could occur. Physicians should be aware of this rare but potentially lethal toxicity when considering systemic therapy for squamous cell carcinoma in patients diagnosed with Xeroderma pigmentosum.
Keyphrases
- dna repair
- squamous cell carcinoma
- oxidative stress
- end stage renal disease
- dna damage
- induced apoptosis
- newly diagnosed
- primary care
- chronic kidney disease
- prognostic factors
- case report
- cell cycle arrest
- cell proliferation
- signaling pathway
- peritoneal dialysis
- lymph node metastasis
- dna damage response
- cell death
- drug induced
- patient reported outcomes
- rectal cancer
- oxide nanoparticles