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Symptom interval and treatment burden for patients with malignant central nervous system germ cell tumours.

James HaydenMatthew Jonathan MurrayUte BartelsThankamma AjithkumarBrinda MuthusamyAnthony PennGabriele CalaminusJames Nicholson
Published in: Archives of disease in childhood (2019)
One-third of patients with CNS-GCT have >6 months of symptoms prior to diagnosis. Delayed diagnosis is associated with metastatic disease. Early symptom recognition, particularly related to visual and hormonal disturbances in the absence of RICP, may improve timely diagnosis, reduce metastatic disease frequency and consequently reduce treatment burden and late effects.
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