Total and Unbound Pharmacokinetics of Cefiderocol in Critically Ill Patients.

Noël ZahrSaik UrienBenoit LlopisGaëlle NoéNadine TissotKevin BihanHelga JunotClémence MarinBochra MansourCharles-Edouard LuytAlexandre Bleibtreu Christian Funck-Brentano

Published in: Pharmaceutics (2022)

This study showed that albumin binding and CKD effects were significant predictors of unbound and total plasma cefiderocol concentrations. Our results indicate that individual adjustment of cefiderocol can be used to reach high minimum inhibitory concentrations based on an estimation of unbound drug concentration and optimize therapeutic efficacy.

Keyphrases

gram negative
multidrug resistant
chronic kidney disease
emergency department
binding protein
adverse drug
drug induced
dna binding
electronic health record